Portsmouth is a city located in Scioto County, along the Ohio River. According to the 2020 census, it has a population of 19,909 people, making it the second-largest city in the county. Some of the places of interest in Portsmouth include the Floodwall Murals, which depict the history and culture of the city; the Southern Ohio Museum, which showcases art and artifacts from the region; and the Shawnee State Park, which offers outdoor recreation and scenic views. The largest employers in Portsmouth are Southern Ohio Medical Center, Shawnee State University, and OSCO Industries, Inc.